Abstract #0569
The subthalamic microlesion in Parkinson's disease: Investigating electrode insertion-related connectivity differences using resting-state fMRI
tefan Holiga 1 , Karsten Mueller 1 , Filip Ruzicka 2 , Duan Urgok 3 , Harald E. Mller 1 , Evzen Ruzicka 2 , Matthias L. Schroeter 1,4 , and Robert Jech 2
1
Max Planck Institute for Human Cognitive and
Brain Sciences, Leipzig, Germany,
2
Department
of Neurology and Center of Clinical Neuroscience, First
Faculty of Medicine, Charles University in Prague, Czech
Republic,
3
Department
of Radiation and Stereotactic Neurosurgery, Na Homolce
Hospital, Prague, Czech Republic,
4
Clinic
for Cognitive Neurology, University of Leipzig, Germany
Microlesion-effect (MLE) is a phenomenon appearing
during implantation of deep-brain stimulation electrodes
in subthalamic nucleus (STN) of patients suffering from
Parkinsons disease (PD). It is associated with
transient, but marked improved of patients motor
symptoms. We took advantage of this invasive
intervention and combined it with hypothesis-free
resting-state fMRI analytical method of eigenvector
centrality, which gave us a unique opportunity to study
the impact of disrupted STN on the motor-circuitry in
human PD in-vivo. We linked several central brain
structures with the MLE. Further, brainstem, cerebellum
and putamen/globus-pallidus were found to account for
improvements in particular PD symptoms.
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