Abstract #0568
Sensitivity of ultra-high field MRS to Recovery from Neurodegeneration in a Conditional Mouse Model: A multi-modal investigation with Histology, Behavioral Testing and Quantitative PCR
Gulin Oz 1 , Emily Colonna 1 , Doene Demirgoez 1 , Orion Rainwater 1 , Lynn E. Eberly 1 , Harry T. Orr 1 , and H. Brent Clark 1
1
University of Minnesota, Minneapolis, MN,
United States
A conditional transgenic mouse model of spinocerebellar
ataxia type 1 (SCA1) was used to determine if
1
H
MRS reflects the extent of neurodegeneration reversal.
Transgene expression was suppressed from 12-24 weeks and
cerebellar neurochemical profiles of treated and
untreated conditional mice and controls were measured at
9.4T using short echo LASER. The data demonstrate that
ultra-high field MRS accurately reflects the extent of
recovery from neurodegeneration (based on significant
correlations with histology and residual transgene
expression by qPCR) and is more sensitive than the
standard motor behavioral testing (Rotarod) in detecting
treatment effects.
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