Functional lung MRI for non-invasive monitoring of regional effects of inhaled hypertonic saline in children with cystic fibrosis
Sajoscha A. Sorrentino 1 , Julius Renne 1 , Christian Schoenfeld 1 , Jan Hinrichs 1 , Marcel Gutberlet 1 , Andreas Voskrebenzev 1 , Burkhard Tuemmler 2 , Frank Wacker 1 , and Jens Vogel-Claussen 1
Radiology, Hannover Medical School,
Pulmonology, Hannover Medical School, Hannover, Germany
This study shows for the first time a significant
increase in pulmonary blood flow and oxygenation after a
single treatment with inhalation of hypertonic saline
(7% NaCl) in patients with cystic fibrosis, assessed by
functional lung MRI, making it a promising,
non-invasive, radiation-free tool for visualization and
quantification of regional effects in the treatment of
patients with cystic fibrosis.
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