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Abstract #0566

Functional lung MRI for non-invasive monitoring of regional effects of inhaled hypertonic saline in children with cystic fibrosis

Sajoscha A. Sorrentino 1 , Julius Renne 1 , Christian Schoenfeld 1 , Jan Hinrichs 1 , Marcel Gutberlet 1 , Andreas Voskrebenzev 1 , Burkhard Tuemmler 2 , Frank Wacker 1 , and Jens Vogel-Claussen 1

1 Radiology, Hannover Medical School, Hannover, Germany, 2 Pediatric Pulmonology, Hannover Medical School, Hannover, Germany

This study shows for the first time a significant increase in pulmonary blood flow and oxygenation after a single treatment with inhalation of hypertonic saline (7% NaCl) in patients with cystic fibrosis, assessed by functional lung MRI, making it a promising, non-invasive, radiation-free tool for visualization and quantification of regional effects in the treatment of patients with cystic fibrosis.

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