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Abstract #0554

ASSESSING MYELOMA BONE DISEASE WITH WHOLE BODY DIFFUSION WEIGHTED IMAGING (WB-DWI): COMPARISON WITH X-RAY SKELETAL SURVEY (SS) AND LABORATORY ESTIMATES OF DISEASE BURDEN

Sharon L Giles 1 , Nandita M DeSouza 2 , David J Collins 2 , Veronica A Morgan 1 , Sharon West 3 , Faith E Davies 3 , Gareth J Morgan 3 , and Christina Messiou 4

1 Clinical Magnetic Resonance Unit, Royal Marsden Hospital, Sutton, Surrey, United Kingdom, 2 Clinical Magnetic Resonance Unit, Institute of Cancer Research, Sutton, Surrey, United Kingdom, 3 Haemato-oncology Department, Royal Marsden Hospital, Sutton, Surrey, United Kingdom, 4 Department of Radiology, Royal Marsden Hospital, Sutton, Surrey, United Kingdom

WB-DWI offers an alternative to SS for detection of myeloma bone disease. This prospective study compared extent of disease shown by WB-DWI and SS by body region (measured by image scores) and correlated the imaging burden of disease (measured by scores and ADC metrics) with the pathological assessment of disease (measured by serum paraprotein and bone marrow histology). WB-DWI scores were significantly higher than SS scores per patient and in every body region except the skull. WB-DWI scores were higher in those with a high disease burden, but there were no significant correlations between imaging and pathological measures of disease.

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