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Abstract #0553

Diffusion-weighted MRI of advanced ovarian cancer: evaluation of the variability of overall disease burden assessment methods

Jennifer C Wakefield 1,2 , Stavroula Kyriazi 1 , Jessica M Winfield 1 , Veronica A Morgan 2 , Sharon L Giles 2 , David J Collins 1,2 , and Nandita M deSouza 1,2

1 Division of Radiotherapy and Imaging, The Institute of Cancer Research, Sutton, Surrey, United Kingdom, 2 Royal Marsden NHS Foundation Trust, Sutton, Surrey, United Kingdom

Variability of tumor volumetry and ADC in ovarian cancer metastases was assessed in order to establish their value as response biomarkers. Three tumor burden assessment methods were employed (semi-automated region growing and manual segmentation of DW-MRI data and RECIST measurements on CT) and tumor volume and median ADC determined in 16 patients with primary ovarian cancer by a single radiologist. A second radiologist assessed the tumor burden using an identical semi-automated region growing method. Intra- and inter-observer variabilities were evaluated by calculating the Coefficient of Variation (CV). Volume variability was: intra-observer CV 12.3%, inter-observer CV 17.4%, median ADC variability was lower: intra-observer CV 4.3%, inter-observer CV 4.2%.

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