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Abstract #0527

Automated correction method allowing phase-based detection of contrast enhancement in DCE-MRI

Ellis Beld 1 , Frank F.J. Simonis 1 , Johannes G. Korporaal 1 , Uulke A. van der Heide 2 , and Cornelis A.T. van den Berg 1

1 Radiotherapy, UMC Utrecht, Utrecht, Netherlands, 2 Radiotherapy, Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital (NKI-AVL), Amsterdam, Netherlands

Phase-sensitive MR procedures are affected by spatially and temporally varying B0 inhomogeneities. A higher order background phase correction, to compensate for these inhomogeneities, was used for phase-based measurement of the arterial input function (AIF) in dynamic contrast-enhanced (DCE) MRI. The background phase was calculated inwards from the subcutaneous fat layer, using a near-harmonic 2D reconstruction. Besides measurement of the AIF, the background corrected phase data enables detection of contrast induced phase modulation in tissues.

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