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Abstract #0526

Measurement of a High-Temporal Resolution Arterial Input Function from MR Projections: Extension to Radial Acquisition to Compensate for Local Tissue Enhancement

Jen Moroz 1 , Piotr Kozlowski 2,3 , and Stefan A Reinsberg 1

1 Physics and Astronomy, University of British Columbia, Vancouver, BC, Canada, 2 Radiology, UBC, University of British Columbia, BC, Canada, 3 UBC MRI Research Centre, University of British Columbia, BC, Canada

The arterial input function is an important input parameter for modelling DCE-MRI data. However, it is difficult to measure accurately in mice. A projection-based method can significantly improve the temporal resolution of the AIF, but may be biased due to local tissue enhancement. This simulation study extends the Cartesian projection-based method to a radial approach: Each projection serves as a single time-point measure of the AIF, but is also used to reconstruct a radial image to assess background tissue enhancement. The results show that an AIF, measured from single projections, can be corrected from a time-series of radial images to remove the bias caused from local tissue enhancement.

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