Abstract #0526
Measurement of a High-Temporal Resolution Arterial Input Function from MR Projections: Extension to Radial Acquisition to Compensate for Local Tissue Enhancement
Jen Moroz 1 , Piotr Kozlowski 2,3 , and Stefan A Reinsberg 1
1
Physics and Astronomy, University of British
Columbia, Vancouver, BC, Canada,
2
Radiology,
UBC, University of British Columbia, BC, Canada,
3
UBC
MRI Research Centre, University of British Columbia, BC,
Canada
The arterial input function is an important input
parameter for modelling DCE-MRI data. However, it is
difficult to measure accurately in mice. A
projection-based method can significantly improve the
temporal resolution of the AIF, but may be biased due to
local tissue enhancement. This simulation study extends
the Cartesian projection-based method to a radial
approach: Each projection serves as a single time-point
measure of the AIF, but is also used to reconstruct a
radial image to assess background tissue enhancement.
The results show that an AIF, measured from single
projections, can be corrected from a time-series of
radial images to remove the bias caused from local
tissue enhancement.
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