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Abstract #0522

Simplified model for Gd-EOB-DTPA DCE-MRI liver function analysis

Mikael F. Forsgren 1,2 , Jose L. Ulloa 3 , and Paul D. Hockings 4,5

1 Wolfram MathCore AB, Linkping, Sweden, and Center for Medical Image Science and Visualization(CMIV), Linkping University, Linkping, Sweden, 2 Dept. of Medical and Health Sciences, Linkping University, Dept. of Radiation Physics, UHL County Council of stergtland, Linkping, Sweden, 3 Bioxydyn Ltd., Manchester, United Kingdom, 4 Drug Safety and Metabolism, AstraZeneca AB, Mlndal, Sweden, 5 MedTech West, Chalmers University of Technology, Gothenburg, Sweden

Dynamic contrast-enhanced MRI seems promising for non-invasive quantification of liver function. Recently a model based method for the quantification was published, and herein we tested if the number of parameters could be reduced by linearizing the efflux into the bile (MRP2), and still maintain sufficient separation between normal and reduced liver function. This model reduction was tested on rats treated with a chemokine receptor antagonist that reduces liver function. We found that the uptake of contrast was unaffected by the model reduction of the efflux, and that the reduced model was significantly able to separate between normal and reduced function.

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