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Abstract #0521

Pronounced Visibility of Cerebral Venous Vasculature in Small Vessel Disease; A Susceptibility-weighted Imaging Study

Farhang F Jalilian 1,2 , David E Crane 1 , FuQiang Gao 1 , Sandra E Black 1,3 , and Bradley J MacIntosh 1,2

1 Heart and Stroke Foundation Canadian Partnership for Stroke Recovery, Sunnybrook Research Institute, Toronto, ON, Canada, 2 Medical Biophysics, University of Toronto, Toronto, ON, Canada, 3 Division of Neurology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada

Cerebral Small Vessel Disease (SVD) is the most prevalent disease that affects the brain. We investigate the use of susceptibility-weighted imaging (SWI) in visualizing medullary veins and assessing the SVD. The study involves automatic segmentation of: 1) venous vasculature and 2) white matter lesions. Our results show there is a higher vein fraction in white matter lesions compared to normal white matter, and a positive correlation between periventricular vein fraction and SVD lesion burden. Our findings showcase the utility of SWI and highlight the importance of investigating the venous vasculature for its involvement in the etiology of the SVD.

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