Meeting Banner
Abstract #0491

Rapamycin Restores Cerebral Blood Flow and Blood Brain Barrier Integrity in APOE4 Carriers

Ai-Ling Lin 1,2 , Wei Zhang 1 , and Arlan Richardson 2

1 Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States, 2 Cellular & Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States

In the study, we used multi-metric MRI methods to evaluate the treatment efficacy of rapamycin on cerebrovascular functions in mice expressing the human e4 allele of the apolipoprotein E gene (APOE4), which is a risk factor for Alzheimers disease (AD). We found that young APOE4 mice treated with rapamycin had significantly restored cerebral blood flow and blood brain barrier integrity compared to the non-treated group, and the effects were prominent over time. The restored cerebrovascular functions in the APOE4 mice resembled those of age-matched wild-type mice. Our results suggest that rapamycin would be promising for future treatment/prevention of AD.

This abstract and the presentation materials are available to members only; a login is required.

Join Here