Abstract #0490
Multi-nutrient diet increases cerebral blood flow and functional connectivity in apoE4 and wildtype mice
Valerio Zerbi 1,2 , Maximilian Wiesmann 3 , Diane Jansen 1 , Laus M Broersen 4 , Christian F Beckmann 5 , Arend Heerschap 2 , and Amanda J Kiliaan 1
1
Anatomy, Donders Institute for Brain
Cognition & Behaviour, Radboud University Nijmegen
Medical Centre, Nijmegen, Netherlands,
2
Radiology,
Radboud University Nijmegen Medical Centre, Nijmegen,
Netherlands,
3
Geriatric
Medicine, Radboud University Nijmegen Medical Centre,
Nijmegen, Netherlands,
4
Nutricia Advanced
Medical Nutrition, Danone Research, Centre for
Specialised Nutrition, Wageningen, Netherlands,
5
MIRA
Institute for Biomedical Technology and Technical
Medicine, University of Twente, Enschede, Netherlands
A specific combination of omega-3 fatty acids with
precursors and cofactors in membrane synthesis was
developed for the dietary management of AD, specifically
to enhance the formation of neuronal membranes and
synapses. In this study, we tested the hypothesis that a
specific multi-nutrient diet is able to positively
influence brain connectivity and vascular health in a
mouse model for AD vascular risk factor (apoE4). Resting
state functional MRI and cerebral blood flow were
assessed by MRI at 11.7T. Results showed enhanced
perfusion, increased neural connectivity; and increased
number of post-synapses in animals fed with a
multi-nutrient diet.
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