Abstract #0450
Assessment of Intratumoral Heterogeneity of Vascularity in Renal Masses with Arterial Spin Labeling (ASL) and Dynamic Contrast Enhanced (DCE) MRI at 3T
Yue Zhang 1 , Ananth Madhuranthakam 1,2 , Qing Yuan 1 , Ivan Dimitrov 2,3 , Yin Xi 1 , Naira Muradyan 4 , Vitaly Margulis 5 , James Brugarolas 6,7 , Payal Kapur 8 , and Ivan Pedrosa 1,2
1
Radiology, UT Southwestern Medical Center,
Dallas, Texas, United States,
2
Advanced
Imaging Research Center, UT Southwestern Medical Center,
Dallas, Texas, United States,
3
Philips
Medical Systems, Cleveland, Ohio, United States,
4
iCAD,
Inc., Nashua, New Hampshire, United States,
5
Urology,
UT Southwestern Medical Center, Dallas, Texas, United
States,
6
Internal
Medicine, UT Southwestern Medical Center, Dallas, Texas,
United States,
7
Developmental Biology, UT
Southwestern Medical Center, Dallas, Texas, United
States,
8
Pathology,
UT Southwestern Medical Center, Dallas, Texas, United
States
The purpose of this study was to investigate the
correlation between
in
vivo
assessments
of vascular heterogeneity within renal masses measured
by arterial spin labeling (ASL) MRI and dynamic
contrast-enhanced (DCE) MRI techniques at 3T.
Quantitative ASL and DCE parameters were obtained from
the whole tumor, and from areas with high- and low-
blood flow within the tumor. ASL measured blood flow in
renal masses correlates with DCE-derived parameters of
tumor vascularity. Both ASL and DCE MRI at 3T allow for
detection of intra-tumoral vascular heterogeneity in
renal masses, providing a tool for assessment and
monitoring of angiogenesis in renal cancer.
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