Meeting Banner
Abstract #0449

A two-compartment model with automatic time interval selection for estimation of GFR using DCE-MRI in cohort of 28 survivors of unilateral Wilms tumor

Aaryani Tipirneni-Sajja 1,2 , Ralf B Loeffler 1 , Niels Oesingmann 3 , Yutong Duan 1 , Adam M Winchell 1,2 , Ruitian Song 1 , Beth McCarville 1 , Melissa Hudson 4 , Sherri L Spunt 4 , and Claudia M Hillenbrand 1

1 Radiological Sciences, St. Jude Children's Research Hospital, Memphis, TN, United States, 2 Biomedical Engineering, University of Memphis, Memphis, TN, United States, 3 Siemens Medical Solutions USA, Inc, New York, NY, United States, 4 Oncology, St. Jude Children's Research Hospital, Memphis, TN, United States

Renal GFR is a very important quantitative index of renal function in health and disease. Several methods are available to estimate GFR using DCE-MRI, but a precise and unbiased method to estimate GFR remains to be developed. This study estimates GFR by DCE-MRI using a two-compartment (2C) model that disregards tubular outflow and automatically picks the end-of-uptake point (auto2C) and compares these results with those from the gold standard GFR measurement (99mTc-DTPA) in long-term survivors of unilateral Wilms tumor.

This abstract and the presentation materials are available to members only; a login is required.

Join Here