Abstract #0394
Quantifying the contribution of white matter microstructure to frequency contrast in gradient echo MRI
Samuel Wharton 1 and Richard Bowtell 1
1
Sir Peter Mansfield Magnetic Resonance
Centre, School of Physics and Astronomy, University of
Nottingham, Nottingham, United Kingdom
In most studies involving GE phase imaging, it is
assumed that the dominant source of phase contrast is
the variation in magnetic susceptibility across
different tissues. Recent studies have suggested that
white matter microstructure may be an additional source
of phase contrast. In this study, we quantify the
frequency contribution of white matter microstructure in
a small tissue phantom by using sophisticated simulation
techniques to model and remove the frequency
contribution of bulk isotropic and anisotropic magnetic
susceptibility. This approach also yields accurate
estimates of the isotropic (-82 ppb) and anisotropic (11
ppb) susceptibility of white matter.
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