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Abstract #0393

Combined NODDI and qMT for full-brain g-ratio mapping with complex subvoxel microstructure

Jennifer S.W. Campbell 1 , Nikola Stikov 1 , Robert F. Dougherty 2 , and G. Bruce Pike 1,3

1 McConnell Brain Imaging Centre, McGill University, Montreal, Quebec, Canada, 2 Stanford Center for Neurobiological Imaging, Stanford University, Stanford, California, United States, 3 Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada

The myelin g-ratio is a fundamental metric that can be computed from combined diffusion and quantitative magnetization transfer (qMT) imaging. The g-ratio is a function of the fiber volume fraction (FVF) and the myelin volume fraction (MVF). The FVF may be obtained from diffusion tensor imaging, but only in the case where the MRI voxels contain a single fiber system with parallel, straight fibers, making the FA an unsuitable measure of FVF for full-brain quantitative maps. Here, we apply the Neurite Orientation Dispersion and Density Imaging (NODDI) model to obtain full brain g-ratio maps.

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