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Abstract #0391

The physical basis of inhomogeneous magnetization transfer

Scott D. Swanson 1 , David C. Alsop 2,3 , and Dariya I. Malyarenko 1

1 Department of Radiology, University of Michigan, Ann Arbor, MI, United States, 2 Beth Israel Deaconess Med. Ctr, Boston, MA, United States, 3 Radiology, Harvard Medical School, Boston, MA, United States

Recent studies have shown that inhomogeneous magnetization transfer (ihMT) can be created in white matter and certain lipid systems by RF saturation at +/- off-resonance frequencies. This work reports on observation of MT and ihMT as a function of temperature in model lipid systems. Our results show that the structure and dynamics of lipids at low temperatures create ihMT which decreases with increasing temperature and is gradually converted into conventional MT by 65 C. Both MT and ihMT disappear as the sample melts at the 85 C. A consistent theoretical explanation of ihMT nature is provided in terms of selective dipolar dynamics in model lipid systems.

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