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Abstract #0390

Functional MRI reveals the reliable brain modulation effect induced by focused ultrasound

HSIN-YI LAI 1,2 , PO-CHUN CHU 3 , HSIANG-WEI HU 4 , YOU-YIN CHEN 5 , YEN-YU IAN SHIH 6 , and YU-CHENG PEI 1,2

1 School of Medicine, Chang Gung University, Taoyuan, Taiwan, 2 Department of Physical Medicine and Rehabilitation, Chang-Gung Memorial Hospital, Taoyuan, Taiwan, 3 Electrical Engineering, Chang Gung University, Taoyuan, Taiwan, 4 Department of Biomedical Engineering, National Yang-Ming University, Taipei, Taiwan, 5 National Yang-Ming University, Taipei, Taiwan, 6 Department of Neurology, Biomedical Research Imaging Center, University of North Carolina, Chapel Hill, NORTH CAROLINA, United States

This study demonstrates focused ultrasound co-administrated with microbubbles can modulate local brain activities. Focused ultrasound with acoustic pressures of 0.3 MPa produced reliable and reversible brain modulation. This present study proposed a novel non-invasive, reversible and localized brain modulated method which is suitable for a variety of neurophysiological experiments and clinical applications.

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