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Abstract #0378

Intravoxel Incoherent Motion MR Imaging shows lower pure molecular diffusion, lower diffusion fraction linked to microcirculation, and lower perfusion-related diffusion in fibrotic livers with a severity correlated manner

Yi-Xiang Wang 1 , Pu-Xuan Lu 2 , Hua Huang 2 , Feng Zhao 1 , and Jing Yuan 1

1 Dept Imaging and Interventional Radiology, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, 2 Department of Radiology, the Shenzhen Third People's Hospital, Shenzhen, Guangdong, China

This current study reports the results of intravoxel incoherent motion (IVIM)-based diffusion weighted imaging evaluation of 17 healthy volunteers and 34 liver fibrosis subjects. Pure molecular diffusion (D), the fraction of the diffusion linked to microcirculation (f), and perfusion-related diffusion (D*) were computed. The results demonstrated all D value, f value, and D* value were significantly lower in the fibrosis livers compared with the healthy livers, and progressively lower as the severity of liver fibrosis increased.

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