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Abstract #0374

Diurnal Variation of Portal Hemodynamics with 4D flow MRI

Alejandro Roldn-Alzate 1 , Camilo A Campo 1 , Kevin M Johnson 2 , Oliver Wieben 1 , and Scott B Reeder 1

1 Radiology, University of Wisconsin, Madison, Wisconsin, United States, 2 Medical Physics, University of Wisconsin, Madison, Wisconsin, United States

The purpose of this study was to evaluate diurnal changes in mesenteric blood flow in normal subjects and patients with portal hypertension using 4D-flow-MRI. Three patients and seven controls were studied. A total of 5 4D-flow-MRI acquisitions were performed along the day to mimic potential imaging schedules. Healthy controls revealed larger changes in blood flow than those in portal hypertension patients. Reduced hemodynamic response in patients may be due to structural and functional vascular changes resulting from cirrhosis. A comprehensive characterization of portal hypertension hemodynamics using 4D-flow MRI would provide valuable information for stratification of variceal bleeding risk in patients.

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