Meeting Banner
Abstract #0373

The influence of inflammation and fibrosis on multifrequency and monofrequency MR elastography parameters: a study in 47 patients with chronic viral hepatitis

Philippe Garteiser 1 , Gaspard D'Assignies 1 , Helena S Leito 2 , Feryel Mouri 3 , Valrie Vilgrain 1,4 , Ralph Sinkus 5 , and Bernard E Van Beers 1,4

1 CRB3, INSERM, Paris, 75018, France, 2 Center for Neuroscience and cell Biology, University of Coimbra, Coimbra, Coimbra, Portugal, 3 Hepatology department, Hpital Beaujon, AP-HP, Clichy, France, 4 Radiology department, Hpital Beaujon, AP-HP, Clichy, France, 5 Division of Imaging Sciences and Biomedical Engineering, King's College London, London, United Kingdom

The quantification of liver inflammation has an important clinical impact in chronic liver diseases such as nonalcoholic steatohepatitis and viral hepatitis. Yet, accurate and noninvasive methods for assessing liver inflammation are lacking, and histopathological analysis of liver biopsies remains the gold standard despite its invasiveness and lack of spatial coverage. In this MR elastography study on patients with viral hepatitis, the wave scattering coefficient, a multifrequency mechanical parameter, is found to be mainly determined by inflammation independently from underlying levels of fibrosis. Thus, the measurement of fibrosis and inflammation can reliably be quantified in an independent fashion with MRE.

This abstract and the presentation materials are available to members only; a login is required.

Join Here