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Abstract #0368

Sodium ( 23 Na) MR Imaging in Pediatric Astrocytomas

Vincent Kyu Lee 1 , Rafael Ceschin 1 , Yongxian Qian 2,3 , Fernando Boada 4 , James Mountz 5 , Regina Jakacki 6 , Ian Pollack 7 , and Ashok Panigrahy 2

1 Radiology, University of Pittsburgh, Pittsburgh, Pa, United States, 2 Radiology, University of Pittsburgh, Pa, United States, 3 Bioengineering, University of Pittsburgh, Pa, United States, 4 Radiology, New York University, NY, United States, 5 University of Pittsburgh, Pa, United States, 6 Pediatrics, University of Pittsburgh, Pa, United States, 7 Pediatric Neurosurgery, University of Pittsburgh, Pa, United States

In this study we report the alterations in sodium intensity observed in a spectrum of pediatric gliomas using 23Na MR imaging to characterize the changes. Pediatric astrocytoma patients (total=26; brainstem gliomas (n=10), low grade (n=6), and high grade (n=10) supratentorial gliomas) at different points of therapy were scanned on clinical 3T MRI scanner. An overall increase in sodium concentration in the brain tumors compared to normal appearing grey and white matter is observed, and the heterogeneous tumor response is demonstrated in supratentorial gliomas. Overall results show the viability of sodium scans as a supplement to clinical scans.

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