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Abstract #0366

Accuracy of Tissue Heterogeneity Corrected MRI-based Treatment Planning in Brain Radiation Therapy

Dilini S. Pinnaduwage 1 , Morgan Yee 1 , Martina Descovich 1 , Josephine Chen 1 , Atchar Sudhyadhom 1 , Ken-Pin Hwang 2,3 , Andras Osztroluczki 4 , and Jean Pouliot 1

1 Department of Radiation Oncology, University of California San Francisco, San Francisco, CA, United States, 2 Global MR Applications and Workflow, GE Healthcare, Houston, TX, United States, 3 Department of Imaging Physics, The University of Texas M.D. Anderson Cancer Center, Houston, TX, United States, 4 Advantage Workstation Applications, GE Healthcare, Szeged, Hungary

MRI is a necessity for tumor delineation in radiation therapy planning for most cases because it allows the visualization of soft tissue differences. However, the current radiation therapy process uses CT for dose calculation in treatment planning because CT image intensities, unlike MR image intensities show a clear relationship with tissue electron densities, allowing for dose calculation. Thus, MR-CT co-registration is used to transfer the target contours from MRI to CT. The purpose of our work is to determine the accuracy of MRI-based dose calculations by using an automated method to generate a pseudo CT from an input MRI.

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