Abstract #0358
In vivo high-resolution diffusion tensor imaging shows progressive changes in hippocampal subfields after status epilepticus in rat
Tuukka Miettinen 1 , Raimo Salo 1 , Heikki Yli-Ollila 1 , Teemu Laitinen 1 , Juhana Sorvari 1 , Asla Pitknen 1,2 , Olli Grhn 1 , and Alejandra Sierra 1
1
Department of Neurobiology, A. I. Virtanen
Institute for Molecular Sciences, University of Eastern
Finland, Kuopio, Finland,
2
Department
of Neurology, Kuopio University Hospital, Kuopio,
Finland
In this study, our hypothesis was that
in
vivo
DTI
is able to detect progression of microstructural
alterations in the hippocampus and in other white matter
and grey matter areas during the early stages of
epileptogenesis. Rats were scanned using
in
vivo
high
resolution DTI before, and 10, 20, 34 and 79 days after
status epilepticus induced by kainic acid or pilocarpine.
We found robust and progressive changes in fractional
anisotropy, axial, linear and spherical diffusivities
and also in the orientation of principal diffusion
direction in the hippocampus and other brain areas
throughout the brain. These findings have potential to
serve as predictive biomarkers for epilepsy in the
future.
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