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Abstract #0358

In vivo high-resolution diffusion tensor imaging shows progressive changes in hippocampal subfields after status epilepticus in rat

Tuukka Miettinen 1 , Raimo Salo 1 , Heikki Yli-Ollila 1 , Teemu Laitinen 1 , Juhana Sorvari 1 , Asla Pitknen 1,2 , Olli Grhn 1 , and Alejandra Sierra 1

1 Department of Neurobiology, A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland, 2 Department of Neurology, Kuopio University Hospital, Kuopio, Finland

In this study, our hypothesis was that in vivo DTI is able to detect progression of microstructural alterations in the hippocampus and in other white matter and grey matter areas during the early stages of epileptogenesis. Rats were scanned using in vivo high resolution DTI before, and 10, 20, 34 and 79 days after status epilepticus induced by kainic acid or pilocarpine. We found robust and progressive changes in fractional anisotropy, axial, linear and spherical diffusivities and also in the orientation of principal diffusion direction in the hippocampus and other brain areas throughout the brain. These findings have potential to serve as predictive biomarkers for epilepsy in the future.

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