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Abstract #0349

Changes over time of brain perfusion and cerebral vasoreactivity after stroke: preliminary results

Olivier Heck 1,2 , Johan Pietras 3 , Thomas Perret 4 , Agns Aghetti 1,3 , Marie-Charlotte Plichta 1,3 , Irne Troprs 4,5 , Sylvie Grand 1 , Olivier Detante 5,6 , Assia Jaillard 3,7 , and Alexandre Krainik 1,5

1 Department of Neuroradiology and MRI, University Hospital of Grenoble, Grenoble, France, 2 Department of Neuroradiology, University Hospital of Nancy, Nancy, France, 3 UMS IRMaGe, Grenoble, France, 4 Inserm U836, Grenoble Institute of Neurosciences, Grenoble, France, 5 University Joseph Fourier, Grenoble, France, 6 Stroke Unit, University Hospital of Grenoble, Grenoble, France, 7 Research Department, University Hospital of Grenoble, Grenoble, France

Purpose: To investigate changes over time of cerebral perfusion and CO2 vasoreactivity (CVR) after anterior stroke using MRI. Methods: Basal perfusion with dynamic susceptibility contrast, and CVR with BOLD contrast measured in 16 stroke subjects at 35, 50, and 180 days after stroke onset. Results: Basal perfusion decreased in both necrotic and perinecrotic rim. In the undamaged MCA territory, perfusion remained stable over time. CVR increased in the perinecrotic rim, but remained stable in the necrosis and the undamaged MCA territory. Conclusion: These preliminary results suggest functional improvement of the perilesional vasculature during the first 180 days after stroke.

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