Abstract #0349
Changes over time of brain perfusion and cerebral vasoreactivity after stroke: preliminary results
Olivier Heck 1,2 , Johan Pietras 3 , Thomas Perret 4 , Agns Aghetti 1,3 , Marie-Charlotte Plichta 1,3 , Irne Troprs 4,5 , Sylvie Grand 1 , Olivier Detante 5,6 , Assia Jaillard 3,7 , and Alexandre Krainik 1,5
1
Department of Neuroradiology and
MRI, University Hospital of Grenoble, Grenoble,
France,
2
Department
of Neuroradiology, University Hospital of Nancy,
Nancy, France,
3
UMS
IRMaGe, Grenoble, France,
4
Inserm
U836, Grenoble Institute of Neurosciences,
Grenoble, France,
5
University
Joseph Fourier, Grenoble, France,
6
Stroke
Unit, University Hospital of Grenoble, Grenoble,
France,
7
Research
Department, University Hospital of Grenoble,
Grenoble, France
Purpose: To investigate changes over time of
cerebral perfusion and CO2 vasoreactivity (CVR)
after anterior stroke using MRI. Methods: Basal
perfusion with dynamic susceptibility contrast,
and CVR with BOLD contrast measured in 16 stroke
subjects at 35, 50, and 180 days after stroke
onset. Results: Basal perfusion decreased in
both necrotic and perinecrotic rim. In the
undamaged MCA territory, perfusion remained
stable over time. CVR increased in the
perinecrotic rim, but remained stable in the
necrosis and the undamaged MCA territory.
Conclusion: These preliminary results suggest
functional improvement of the perilesional
vasculature during the first 180 days after
stroke.
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