Abstract #0348
Quantifying cerebral haemodynamics and maximum potential oxygen delivery in patients with chronic ischemia using DSC perfusion MRI
Amit Mehndiratta 1 , Chang Sub Park 1 , David E Crane 2 , Bradley J MacIntosh 2 , Stephen J Payne 1 , and Michael A Chappell 1
1
Institute of Biomedical Engineering,
University of Oxford, Oxford, Oxfordshire,
United Kingdom,
2
Medical
Biophysics, Sunnybrook Research Institute,
University of Toronto, Toronto, ON, Canada
Estimation of capillary haemodynamics has
historically been a challenge in DSC-MRI
analysis. With the Control Point Interpolation
method it is now possible to study variation in
residue function and haemodynamics in-vivo. This
study examined the changes in tissue
haemodynamics, maximum potential oxygen delivery
corresponding maximum potential tissue metabolic
activity in a cohort of seventeen patients with
atherosclerotic diseases both pre- and
post-carotid endarterectomy. It was found that
capillary heterogeneity increased in ischemic
tissue, which would be associated with an
increase in maximum tissue oxygen extraction
fraction that could assist the tissue to
maintain normal metabolic activity.
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