Meeting Banner
Abstract #0346

Evaluation of Lesion Severity in Transient MCAO Rat Brain During Early Reperfusion Using Combined Cerebral Vascular Reactivity and Diffusion Imaging

Xiao Wang 1 , Xiao-Hong Zhu 1 , Afshin A Divani 2 , Yi Zhang 1 , and Wei Chen 1

1 Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota Medical School, Minneapolis, Minnesota, United States, 2 Neurology, University of Minnesota, Minnesota, United States

Ischemic stroke is a leading cause of death and long-term disability in the United States. Tremendous effort has been taken and great progress has been made to detect and treat the ischemic lesion at an early stage. The use of thrombolytic agent such as tissue plasminogen activator (tPA) can be helpful to restore the function of salvageable tissues, however, reperfusion paradoxically may also lead to the secondary cell death concurrently. The severity of the reperfusion lesion was evaluated with the ADC, CVR images at a relatively early stage (24 hours after a 1-hour MCA occlusion) of rat brain and the corresponding histology images were obtained on day 7 of the post-occlusion. The results show that the spatial pattern of declined ADC correlates well with the actual lesion region determined by the histology images, while the compromised CVR with normal ADC turns out to be histologically intact. Therefore, three regions regarding the lesion severity can be identified with combined ADC and CVR images: severe lesion region with both ADC and CVR decreased; mild lesion region with impaired CVR but normal ADC and the normal brain region with intact CVR and ADC. The mismatched areas with compromised CVR but intact ADC at the early stage of reperfusion potentially could serve as the treatment target to improve the clinical outcomes.

This abstract and the presentation materials are available to members only; a login is required.

Join Here