Abstract #0345
BOLD-based characterization of relative oxygen extraction fraction in patients with ischemia
Christine Preibisch 1,2 , Monika Ankenbrank 1 , Alexandra Gersing 1 , Vivien Toth 1 , Nuria Hirsch 1 , Hendrik Kooijman 3 , Silke Wunderlich 2 , and Claus Zimmer 1
1
Neuroradiologie, Klinikum rechts der
Isar, Technische Universitt Mnchen, Munich,
Germany,
2
Neurologische
Klinik und Poliklinik, Klinikum rechts der Isar,
Technische Universitt Mnchen, Munich, Germany,
3
Philips
Healthcare, Hamburg, Germany
Purpose of this study was to evaluate a protocol
for measurement of a relative oxygen extraction
fraction (rOEF) with separate quantification of
T2, T2* and CBV for improved penumbra estimation
in patients with ischemia. Compared to rOEF in
healthy appearing tissue (0.59 0.19), rOEF
presented a stronger increase in areas with
prolonged TTP without diffusion restriction
(1.44 0.85) than in regions with diffusion
restriction (1.03 0.62). rOEF measurement
allows to identify ischemic areas and detects
differences in rOEF between ischemic core and
surrounding tissue. Further work is needed to
delineate utility of rOEF for the penumbra
concept.
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