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Abstract #0305

pH Dependence of gagCEST at 7T

Ravi Prakash Reddy Nanga 1 , Anup Singh 1 , Hari Hariharan 1 , and Ravinder Reddy 1

1 Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, United States

Since gag-CEST is promising at 7T for imaging knee cartilage, we have evaluated the pH sensitivity of gagCEST on 5% chondrotin sulfate phantoms with varying pH from 4-8 at both room temperature as well as at 37 C as there are emerging reports of a pH drop in the knee cartilage of osteoarthritis subjects.

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