Abstract #0304
R 1 (1/T 1 ) dispersion measurement in knee cartilage at 3T
Ping Wang 1,2 and John C Gore 1,2
1
Institute of Imaging Science, Vanderbilt
University, Nashville, Tennessee, United States,
2
Radiology
and Radiological Sciences, Vanderbilt University,
Nashville, Tennessee, United States
T
1
rho variations with spin-locking strength
(= the T
1
rho dispersion) can provide a more
complete characterization of tissue composition and the
physicochemical changes associated with pathology. In
this work,
in
vivo
R
1
rho
(=1/T
1
rho) dispersion of human knee cartilage
(articular and epiphyseal) was studied at 3T. Our data
show pronounced R
1
rho dispersion over
practical locking fields; the mean exchange rate was
measured at ~992 Hz when fitting the data to the Chopra
model. To the best of our knowledge, this is the first R
1
rho
dispersion measurement in human articular/epiphyseal
cartilage, and forms the basis for more quantitative
evaluation of cartilage disorders.
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