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Abstract #0304

R 1 (1/T 1 ) dispersion measurement in knee cartilage at 3T

Ping Wang 1,2 and John C Gore 1,2

1 Institute of Imaging Science, Vanderbilt University, Nashville, Tennessee, United States, 2 Radiology and Radiological Sciences, Vanderbilt University, Nashville, Tennessee, United States

T 1 rho variations with spin-locking strength (= the T 1 rho dispersion) can provide a more complete characterization of tissue composition and the physicochemical changes associated with pathology. In this work, in vivo R 1 rho (=1/T 1 rho) dispersion of human knee cartilage (articular and epiphyseal) was studied at 3T. Our data show pronounced R 1 rho dispersion over practical locking fields; the mean exchange rate was measured at ~992 Hz when fitting the data to the Chopra model. To the best of our knowledge, this is the first R 1 rho dispersion measurement in human articular/epiphyseal cartilage, and forms the basis for more quantitative evaluation of cartilage disorders.

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