Abstract #0300
Assessment of Human Articular Cartilage Using Novel Quantitative MRI Relaxation Parameters with Correlation to Histology and Biomechanical Properties
Jari Rautiainen 1,2 , Elli-Noora Salo 3 , Virpi Tiitu 4 , Mikko A.J. Finnil 5 , Olli-Matti Aho 6 , Simo Saarakkala 3,5 , Petri Lehenkari 6 , Jutta Ellermann 7 , Mikko J. Nissi 7,8 , and Miika T. Nieminen 2,3
1
Department of Applied Physics, University of
Eastern Finland, Kuopio, Eastern Finland, Finland,
2
Department
of Diagnostic Radiology, University of Oulu, Oulu,
Northern Finland, Finland,
3
Department
of Diagnostic Radiology, Oulu University Hospital, Oulu,
Northern Finland, Finland,
4
Institute
of Biomedicine, Anatomy, University of Eastern Finland,
Kuopio, Eastern Finland, Finland,
5
Department
of Medical Technology, University of Oulu, Oulu,
Northern Finland, Finland,
6
Department
of Anatomy and Cell Biology, University of Oulu, Oulu,
Northern Finland, Finland,
7
Center
for Magnetic Resonance Research and Department of
Radiology, University of Minnesota, Minneapolis, MN,
United States,
8
Department
of Orthopaedic Surgery, University of Minnesota,
Minneapolis, MN, United States
The purpose of this study was to evaluate sensitivity of
quantitative MRI techniques for assessment of human
tibial articular cartilage with varying degrees of
degeneration. For reference, biomechanical measurements,
quantitative histology and OARSI grading were performed.
The MRI techniques were able to differentiate early
osteoarthritis and advanced osteoarthritis specimens and
the measures were highly correlated with the
biomechanical parameters as well as OARSI grade.
Rotating frame MRI techniques (adiabatic T1ρ, adiabatic
T2ρ, CW-T1ρ and RAFF) were the most sensitive methods to
detect cartilage degeneration.
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