Meeting Banner
Abstract #0299

Evaluation of pH and vascular perfusion in a lung fibrosis mouse model using respiration gated acidoCEST MRI

Kyle Mitchell Jones 1 , Edward Randtke 2 , Christine Howison 3 , Matt Kottman 4 , Patricia Sime 4 , and Mark Pagel 5

1 Biomedical Engineering, University of Arizona, Tucson, AZ, United States, 2 Physical Chemistry, University of Arizona, AZ, United States, 3 University of Arizona, AZ, United States, 4 University of Rochester, NY, United States, 5 Biomedical Engineering and Chemistry, University of Arizona, Arizona, United States

The pH and vascular perfusion of lung fibrotic tissue were measured using a novel respiration gated acidoCEST MRI method to correlate lung fibrosis and pH. It is thought that a low pH environment will activate TGFβ resulting in the up regulation of fibroblasts leading to scar tissue formation; however, directly measuring lung tissue pH in vivo has not been possible until now. Our results show that respiration gating significantly reduced motion artifacts in the lung allowing for accurate pH and perfusion measurements. Both pH and perfusion were shown to increase as lesion volume decreased thereby supporting the proposed hypothesis.

This abstract and the presentation materials are available to members only; a login is required.

Join Here