Abstract #0299
Evaluation of pH and vascular perfusion in a lung fibrosis mouse model using respiration gated acidoCEST MRI
Kyle Mitchell Jones 1 , Edward Randtke 2 , Christine Howison 3 , Matt Kottman 4 , Patricia Sime 4 , and Mark Pagel 5
1
Biomedical Engineering, University of
Arizona, Tucson, AZ, United States,
2
Physical
Chemistry, University of Arizona, AZ, United States,
3
University
of Arizona, AZ, United States,
4
University
of Rochester, NY, United States,
5
Biomedical
Engineering and Chemistry, University of Arizona,
Arizona, United States
The pH and vascular perfusion of lung fibrotic tissue
were measured using a novel respiration gated acidoCEST
MRI method to correlate lung fibrosis and pH. It is
thought that a low pH environment will activate TGFβ
resulting in the up regulation of fibroblasts leading to
scar tissue formation; however, directly measuring lung
tissue pH in vivo has not been possible until now. Our
results show that respiration gating significantly
reduced motion artifacts in the lung allowing for
accurate pH and perfusion measurements. Both pH and
perfusion were shown to increase as lesion volume
decreased thereby supporting the proposed hypothesis.
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