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Abstract #0296

Ultra-short echo-time MRI distinguishes ischemia/reperfusion injury from acute rejection in a mouse lung transplantation model

Natalie Christine Chuck 1 , Wolfgang Jungraithmayr 2 , Moritz Wurnig 1 , Markus Weiger 3 , and Andreas Boss 1

1 Institute for Diagnostic and Interventional Radiology, University Hospital Zrich, Zrich, Zrich, Switzerland, 2 Division of Thoracic Surgery, University Hospital Zrich, Zrich, Switzerland, 3 Institute for Biomedical Engineering, Swiss Federal Institute for Technology Zrich, Zrich, Zrich, Switzerland

In this study we wanted to show that ultrashort echo-time sequences are capable of identifying and characterizing changes in the lung parenchyma that appear after allogeneic lung transplantation. We used a mouse model and compared the allogeneic transplanted mice to syngeneic transplanted group in order to differentiate the changes from ischemia/reperfusion injury which also often occurs after lung transplantation. Therefore we scanned the animals on three different time points after the transplantation using conventional T2 sequences as well as UTE sequences with different echo times.

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