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Abstract #0295

3D pulmonary perfusion MRI with radial ultra-short echo time and spatial-temporal constrained reconstruction

Grzegorz Bauman 1 , Kevin M Johnson 1 , Laura C Bell 1 , Julia V Velikina 1 , Alexey A Samsonov 1 , Scott K Nagle 1,2 , and Sean B Fain 1,2

1 Department of Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, 2 Department of Radiology, University of Wisconsin-Madison, Madison, WI, United States

In this work we present a novel DCE MRI technique that combines a time-resolved 3D UTE acquisition with constrained reconstruction for assessment of regional lung perfusion. High isotropic spatial resolution is achieved by acquiring undersampled data for each time frame and reconstructing it using dimensionality reduction in temporal domain via principal component analysis and wavelet soft-thresholding in spatial domain. We present feasibility of this technique in simulations using a fractal-based digital lung phantom and in vivo experiment in a human subject.

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