Histopathology of Lung Adenocarcinoma Based on New IASLC/ATS/ERS Classification: Prognostic Stratification With Functional and Metabolic Imaging Biomarkers

A lung adenocarcinoma is a heterogeneous tumor, and it usually consists of variable combinations of two or more histologic subtypes. In the new IASLC/ATS/ERS international multidisciplinary classification of lung adenocarcinoma, invasive adenocarcinomas are reclassified as lepidic, acinar, papillary, and solid subtypes in consideration of their predominant patterns of constituents; in addition, the micropapillary subtype has been added as a new histologic subtype. Previous studies have already used this subclassification system and validated its important prognostic implications. We hypothesized that histological subtypes of lung adenocarcinoma differ in terms of SUVmax in PET and ADC values in DWI. The purpose of our study was to correlate the results of subtyping and grading of lung adenocarcinoma based on new IASLC/ATS/ERS Classification with SUVs at PET/CT and ADC values at DWI.

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