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Abstract #0290

Intratracheal administration of Gd-based nanoparticles: an effective approach for MRI detection and follow-up of lung tumor

Andrea Bianchi 1 , Sandrine Dufort 2,3 , Franois Lux 4 , Nawal Tassali 1 , Pierre-Yves Fortin 1 , Olivier Tillement 4 , Jean-Luc Coll 2 , and Yannick Crmillieux 1

1 Centre de Rsonance Magntique des Systmes Biologiques, Universit Bordeaux Segalen, Bordeaux, Bordeaux, France, 2 Universit Joseph Fourier, Grenoble, France, 3 Nano-H, Saint Quentin-Fallavier, France, 4 Institut Lumire Matire, Universit Claude Bernard, Lyon, France

Lung cancer is the leading cause of cancer deaths worldwide. The burden of this disease could be greatly reduced with an early diagnostics. We present here an in vivo MRI longitudinal study of lung cancer detection in tumor-bearing mice through intratracheally- and intravenously-administered multimodal Ultra-Small Rigid Platforms and a commercial Gd-based contrast agent. The localization of the tumors was validated against bioluminescence imaging and histology. In this study we showed for the first time that the synergic employment of a strongly T1-weighted MRI UTE sequence and high-relaxivity gadolinium-based nanoparticles allow the high-precision detection of lung tumor and of its contours.

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