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Abstract #0275

Perforant pathway tracking in human temporal lobe ex vivo tissue.

Luis Manuel Colon-Perez 1 , Mansi Parekh 2 , Michelle Couret 3 , Rosemary Klassen 3 , Michael King 4 , Paul Carney 5 , and Thomas Mareci 1

1 Biochemistry and Molecular Biology, University of Florida, Gainesville, FL, United States, 2 Radiology, Stanford University, Stanford, CA, United States, 3 University of Florida, FL, United States, 4 Pharmacology and Therapeutics, University of Florida, FL, United States, 5 Pediatrics, University of Florida, FL, United States

The perforant pathway is a bundle of axons that provide direct connections from the entorhinal cortex (EC) to all subfields of the hippocampus (HC). This pathway is a complicated structure difficult to visualize in clinical data. In order to study this pathway, we acquired high spatial resolution diffusion weighted images of excised human tissue, which reduce volume averaging enhancing the ability to resolve this small fiber pathway and employ an advanced model of diffusion displacement which improve tracking for smaller fiber bundles by resolving crossing and kissing fibers. In this study we visualize this pathway using probabilistic and deterministic tractography.

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