Meeting Banner
Abstract #0256

Age-related hypermetabolism in the human brain

Shin-Lei Peng 1,2 , Julie Dumas 3 , Denise Park 1,4 , Peiying Liu 1 , Francesca Filbey 4 , Carrie McAdams 1 , Amy Pinkham 1,5 , Bryon Adinoff 1,6 , Rong Zhang 7 , and Hanzhang Lu 1

1 UT Southwestern Medical Center, Dallas, TX, United States, 2 National Tsing Hua University, Taiwan, 3 University of Vermont College of Medicine, VT, United States, 4 University of Texas Dallas, TX, United States, 5 Southern Methodist University, TX, United States, 6 VA North Texas Health Care System, Dallas, TX, United States, 7 Texas Health Presbyterian Hospital Dallas, TX, United States

In this study, we provide evidence that the brain of older adults works harder when compared to younger adults, as manifested by an age-related increase in cerebral metabolic rate of oxygen (CMRO2) (N=118). We further showed that, prior to the typical menopausal age of 51 years old, female and male groups have similar rates of CMRO2 increase (P=0.003). However, for the entire age range, women have a slower rate of CMRO2 change, when compared to men (P<0.001). Our data also revealed a possible circadian rhythm of CMRO2 in that brain metabolic rate is greater at noon than in the morning.

This abstract and the presentation materials are available to members only; a login is required.

Join Here