Abstract #0255
The Dynamically Changing Default-Mode Network after Concussion in Sports: a Resting-State fMRI and DTI Integration Study
David C Zhu 1 , Tracey Covassin 1 , Sally Nogle 1 , Scarlett Doyle 1 , Doozie Russell 1 , Randy Pearson 1 , Jeffrey Monroe 1 , Christine Liszewski 1 , J. Kevin DeMarco 1 , and David Kaufman 1
1
Michigan State University, East Lansing, MI,
United States
Resting-state fMRI (rs-fMRI) and diffusion tensor
imaging (DTI) were applied to understand the dynamics of
functional and structural connectivity of the
default-mode network (DMN) after concussion. The
functional connectivity within DMN was significantly
higher on Day 1 comparing to Days 7 and 30 after
concussion. Noticeable change in structural connectivity
and gross anatomy were not seen. This sequential change
of DMN functional connectivity was not seen in the
control group. Based on our results, the functional
connectivity of DMN measured with sequential rs-fMRI can
potentially serve as a biomarker to monitor the
dynamically changing brain function after sports-related
concussion.
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