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Abstract #0255

The Dynamically Changing Default-Mode Network after Concussion in Sports: a Resting-State fMRI and DTI Integration Study

David C Zhu 1 , Tracey Covassin 1 , Sally Nogle 1 , Scarlett Doyle 1 , Doozie Russell 1 , Randy Pearson 1 , Jeffrey Monroe 1 , Christine Liszewski 1 , J. Kevin DeMarco 1 , and David Kaufman 1

1 Michigan State University, East Lansing, MI, United States

Resting-state fMRI (rs-fMRI) and diffusion tensor imaging (DTI) were applied to understand the dynamics of functional and structural connectivity of the default-mode network (DMN) after concussion. The functional connectivity within DMN was significantly higher on Day 1 comparing to Days 7 and 30 after concussion. Noticeable change in structural connectivity and gross anatomy were not seen. This sequential change of DMN functional connectivity was not seen in the control group. Based on our results, the functional connectivity of DMN measured with sequential rs-fMRI can potentially serve as a biomarker to monitor the dynamically changing brain function after sports-related concussion.

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