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Abstract #0206

Age-related changes of the bound pool fraction in white matter

Lukas Pirpamer 1 , Florian Franz Erich Borsodi 1 , Gernot Reishofer 2 , Christian Langkammer 1 , Reinhold Schmidt 1 , and Stefan Ropele 1

1 Department of Neurology, Medical University of Graz, Graz, Austria, 2 Department of Radiology, Medical University of Graz, Graz, Austria

The bound pool fraction (BPF) is a fundamental parameter for magnetization transfer and therefore expected to be more sensitive for age-related tissue changes compared to the conventional MTR. This study investigated the change of the BPF in several white-matter regions assessed over age in a normal aging cohort. This study confirms the higher sensitivity of the BPF in particular for WM regions that are susceptible for developing age related white matter hyperintensities.

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