Abstract #0205
Biophysical Abnormalities in Fronto-Striato-Thalamic Circuits in Type 2 Diabetes Revealed by Magnetization Transfer Imaging
Shaolin Yang 1,2 , Olusola Ajilore 1 , Minjie Wu 1 , Melissa Lamar 1 , and Anand Kumar 1
1
Department of Psychiatry, University of
Illinois at Chicago, Chicago, IL, United States,
2
Department
of Radiology, University of Illinois at Chicago,
Chicago, IL, United States
A cross-sectional study using magnetization transfer
ratio (MTR) imaging was performed to examine the
biophysical integrity of macromolecular protein pools in
gray matter and white matter of the
fronto-striato-thalamic circuits in patients with type 2
diabetes mellitus (T2DM) and comparison controls to
determine the impacts of T2DM on the abnormalities of
human brain. Compared with non-diabetic controls, T2DM
patients had significantly lower MTR in dorsal anterior
cingulate cortex (ACC) and head of caudate nucleus (hCaud),
also with a tendency to significance in rostral ACC. The
compromised MTRs were correlated with T2DM-related
clinical measures and neuropsychological performance in
distinct domains.
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