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Abstract #0205

Biophysical Abnormalities in Fronto-Striato-Thalamic Circuits in Type 2 Diabetes Revealed by Magnetization Transfer Imaging

Shaolin Yang 1,2 , Olusola Ajilore 1 , Minjie Wu 1 , Melissa Lamar 1 , and Anand Kumar 1

1 Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, United States, 2 Department of Radiology, University of Illinois at Chicago, Chicago, IL, United States

A cross-sectional study using magnetization transfer ratio (MTR) imaging was performed to examine the biophysical integrity of macromolecular protein pools in gray matter and white matter of the fronto-striato-thalamic circuits in patients with type 2 diabetes mellitus (T2DM) and comparison controls to determine the impacts of T2DM on the abnormalities of human brain. Compared with non-diabetic controls, T2DM patients had significantly lower MTR in dorsal anterior cingulate cortex (ACC) and head of caudate nucleus (hCaud), also with a tendency to significance in rostral ACC. The compromised MTRs were correlated with T2DM-related clinical measures and neuropsychological performance in distinct domains.

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