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Abstract #0202

Quantitative Magnetization Transfer Imaging of Human Sciatic Nerve at 3 Tesla

Richard D. Dortch 1,2 , Lindsey M. Dethrage 2 , Ke Li 1,2 , Bruce M. Damon 1,2 , John C. Gore 1,2 , and Seth A. Smith 1,2

1 Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, United States, 2 Vanderbilt University Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States

Previous work has demonstrated that the macromolecular-to-free proton pool size ratio ( PSR ) is related to myelin content; yet, no studies have reported PSR mapping in peripheral nerves in vivo . This can be attributed to the challenges of quantitative magnetization transfer (qMT) imaging in nerve, including the influence of fat and the need for higher resolution. The goal of this work was to develop qMT approaches for the currently inaccessible (via electrophysiology) sciatic nerves of healthy controls as a baseline for future studies in neuropathy patients. Our findings demonstrate that PSR can be robustly measured in the sciatic nerve in vivo .

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