Abstract #0188
Impact of the Connective Tissue Matrix in the Myocardium on the Restriction of Water Revealed with Diffusion Tensor MRI of a Decellularized Human Heart
Choukri Mekkaoui 1 , Marcel P Jackowski 2 , Sava Sakadzic 3 , Christian T Stoeck 4 , Timothy G Reese 3 , Sebastian Kozerke 5 , Harald C Ott 6 , and David E Sosnovik 7
1
Harvard Medical School - Massachusetts
General Hospital, Boston, MA, United States,
2
Department
of Computer Science, Institute of Mathematics and
Statistics, University of So Paulo, So Paulo, Brazil,
3
Athinoula
A Martinos center for Biomedical imaging, Boston, United
States,
4
Institute
for Biomedical Engineering, University and ETH Zurich,
Zurich, Switzerland,
5
University
and ETH Zurich, Zurich, Switzerland,
6
Massachusetts
General Hospital, Boston, United States,
7
Harvard
Medical School - Massachusetts General Hospital, Boston,
United States
The myocardium consists of a branching network of muscle
fibers and a supporting network of connective tissue
fibers, whose relative contributions to diffusion
restriction remain unknown. We performed high-resolution
DTI and two-photon microscopy of a decellularized human
heart and compared the findings with normal human hearts
and patients with recent myocardial infarction.
Diffusion in the decellularized heart was minimally
restricted, despite a fairly dense, ordered and
anisotropic collagen network. Diffusion restriction in
the myocardium thus reflects its cellular components
with little impact from the connective tissue network at
commonly-used b-values.
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