Meeting Banner
Abstract #0187

Quantification of Diffuse Myocardial Fibrosis and Its Association with Diastolic Dysfunction in Patients with Diastolic Heart Failure Using Cardiovascular Magnetic Resonance

Mao-Yuan Marine Su 1 , Lian-Yu Lin 2 , Chin-Chen Chang 1 , Yao-Hui Elton Tseng 1 , Cho-Kai Wu 2 , Jiunn-Lee Lin 2 , and Wen-Yih Isaac Tseng 1,3

1 Department of Medical Imaging, National Taiwan University Hospital, Taipei, Taiwan, 2 Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan, 3 Center for Optoelectronic Medicine, National Taiwan University College of Medicine, Taipei, Taiwan

This study investigated whether the diastolic dysfunction of left ventricular (LV) was associated with diffuse myocardial fibrosis in patients with diastolic heart failure (DHF). Forty patients with DHF, 27 patients with systolic heart failure (SHF) and 22 patients without heart failure (control) were studied using cardiovascular magnetic resonance. Patients with SHF and DHF both showed increased diffuse myocardial fibrosis and decreased diastolic function as compared to controls. Correlation analysis demonstrated that the extracellular volume fraction (ECV) was significantly correlated with systolic and diastolic function in DHF. There was no significant correlation between ECV and the other functional indices in SHF and non-HF controls. Our findings support that increased diffuse myocardial fibrosis may impair the diastolic function but also affect the systolic function in patients with DHF.

This abstract and the presentation materials are available to members only; a login is required.

Join Here