Abstract #0133
Hemiplegic cerebral palsy and constraint-induced movement therapy: Resting state functional magnetic resonance and diffusion tensor imaging predictors and neuroplastic changes
Kathryn Yvonne Manning 1 , Darcy Fehlings 2 , and Ravi S. Menon 3
1
Medical Biophysics, The University of
Western Ontario, London, Ontario, Canada,
2
Holland
Bloorview Kids Rehabilitation Hospital, University of
Toronto, Toronto, Ontario, Canada,
3
Robarts
Research Institute, The University of Western Ontario,
London, Ontario, Canada
Hemiplegic cerebral palsy patients experience learned
non-use where the hemiplegic arm is further inhibited
from healthy development as most tasks are performed
with the unaffected limb. Constraint-induced movement
therapy (CIMT) has rendered significant functional
improvement in many patients, though not all experience
success and little is known about the possible
neurological predictors. Resting state functional MRI
and diffusion tensor imaging reveal altered global
network organization and quantify white matter tract
integrity. Potential predictors of clinical success are
identified, and resting state network reorganization
after CIMT provides evidence of neuroplasticity.
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