Imaging the developing brain at the bedside: A comparison of diffuse optical tomography and functional MRI
Silvina L. Ferradal 1 , Steve M. Liao 2 , Adam T. Eggebrecht 1 , Joshua S. Shimony 1 , Terrie E. Inder 3 , Joseph P. Culver 1 , and Christopher D. Smyser 2
Radiology, Washington University in St.
Louis, St. Louis, MO, United States,
Washington University in St. Louis, St. Louis, MO,
Harvard Medical School,
Boston, MA, United States
Adverse neurodevelopmental outcomes in preterm infants
remain a clinical challenge. While functional
connectivity (fc) using functional MRI opens a window to
study brain function in neonates, frequent longitudinal
monitoring is often restricted in the sickest infants.
Diffuse optical tomography (DOT) provides a portable
alternative modality for evaluating brain function at
the bedside. Here we demonstrate that our DOT system
generates resting-state maps exhibiting strong agreement
with non-concurrent fcMRI maps in identical subjects.
Our results suggest that fcDOT provides satisfactory
spatial localization and resolution, and illustrates its
potential as a viable imaging tool for bedside
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