Abstract #0130
Brain temperatures during therapeutic hypothermia of birth asphyxia are significantly different in patients with poor outcome versus patients with mild to moderate injury
Stefan Bluml 1,2 , Tai-Wei Wu 3,4 , Ashok Panigrahy 1,5 , John P Grimm 1 , Marvin D Nelson 1 , Thomas G Perkins 6 , Jonathan Chia 6 , and Jessica L Wisnowski 1,5
1
Children's Hospital Los Angeles/USC, Los
Angeles, CA, United States,
2
Rudi
Schulte Research Institute, Santa Barbara, CA, United
States,
3
Neonatology,
Children's Hospital Los Angeles/USC, CA, United States,
4
Linkou
Chang Gung Memorial Hospital, Taoyuan, Taiwan,
5
Children's
Hospital of Pittsburgh, Pittsburgh, PA, United States,
6
Philips
Healthcare, Cleveland, OH, United States
Therapeutic hypothermia (TH) aims to lower brain
temperature to prevent secondary energy failure in
newborns with birth asphyxia. However, newborn brain
temperature during TH is unknown as generally rectal
temperatures are monitored. In this study we show, by
direct brain temperature measurement using MR
spectroscopy, that the brain temperatures during TH were
higher in patients with poor outcome when compared with
patients with mild to moderate injury. It may be
necessary to measure brain temperature directly in
individual patients to ascertain that the targeted level
of cooling has been achieved.
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