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Abstract #0130

Brain temperatures during therapeutic hypothermia of birth asphyxia are significantly different in patients with poor outcome versus patients with mild to moderate injury

Stefan Bluml 1,2 , Tai-Wei Wu 3,4 , Ashok Panigrahy 1,5 , John P Grimm 1 , Marvin D Nelson 1 , Thomas G Perkins 6 , Jonathan Chia 6 , and Jessica L Wisnowski 1,5

1 Children's Hospital Los Angeles/USC, Los Angeles, CA, United States, 2 Rudi Schulte Research Institute, Santa Barbara, CA, United States, 3 Neonatology, Children's Hospital Los Angeles/USC, CA, United States, 4 Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan, 5 Children's Hospital of Pittsburgh, Pittsburgh, PA, United States, 6 Philips Healthcare, Cleveland, OH, United States

Therapeutic hypothermia (TH) aims to lower brain temperature to prevent secondary energy failure in newborns with birth asphyxia. However, newborn brain temperature during TH is unknown as generally rectal temperatures are monitored. In this study we show, by direct brain temperature measurement using MR spectroscopy, that the brain temperatures during TH were higher in patients with poor outcome when compared with patients with mild to moderate injury. It may be necessary to measure brain temperature directly in individual patients to ascertain that the targeted level of cooling has been achieved.

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