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Abstract #0129

Exploring the diffusivity changes of diffuse excessive high signal intensity (DEHSI) in preterm neonates by using two-compartment white matter model based on DKI

Jie Gao 1 , Xianjun Li 1,2 , Yumiao Zhang 1 , Yanyan Li 1 , Qinli Sun 1 , Xue Luo 1,2 , Bolang Yu 1 , and Jian Yang 1,2

1 Department of radiology, the first affiliated hospital of medical college, Xi'an Jiaotong University, Xi'an, Shannxi, China, 2 Biomedical Engineering, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, Shannxi, China

Diffuse excessive high signal intensity (DEHSI) is extremely common in preterm infants. Its still under debate about whether it represents a true white mater(WM) abnormality or just the relative immature in WM. Two-compartment WM model based on DKI can provides analytical expressions for the intra- and extra-axonal diffusion tensors and may be helpful in further exploring the diffusivity changes in DEHSI. So in this study, 8 preterm neonates with DEHSI and 8 matched controls who underwent MRI at term-equivalent age were enrolled. All diffusion parameters(FA=fractional anisotropy, MD=mean diffusivity, AD=axial diffusivity, RD=radial diffusivity, MK=mean kurtosis, AK=axial kurtosis, RK=radial kurtosis, AWF= axonal water fraction, Da=intra-axonal diffusivity, De=axial extra-axonal space diffusivity, De= radial extra-axonal space diffusivity, =tortuosity) were compared between the two groups. The increased MD, AD, RD, De, De and no significantly changed MK, AK, RK, Da, AWF indicated that the diffusion changes in DEHSI were mainly due to the increased water and/or enlarged space in extra-axonal space, rather than injuries to axons or the process of myelination.

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