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Abstract #0119

Contralateral cerebello-thalamo-cortical pathways with prominent involvement of associative areas in humans in vivo

Fulvia Palesi 1,2 , Donald Tournier 3,4 , Fernando Calamante 3,4 , Nils Muhlert 5,6 , Gloria Castellazzi 2,7 , Declan Chard 5,8 , Egidio D'Angelo 2,9 , and Claudia A. M. Wheeler-Kingshott 5

1 Department of Physics, University of Pavia, Pavia, Pavia, Italy, 2 Brain Connectivity Center, National Neurological Institute C. Mondino, Pavia, Pavia, Italy, 3 The Florey Institute of Neuroscience and Mental Health, Melbourne Brain Centre, Heidelberg, Australia, 4 Department of Medicine, Austin Health and Northern Health, University of Melbourne, Heidelberg, Australia, 5 NMR Research Unit, Department of Neuroinflammation, Queen Square MS Centre, UCL Institute of Neurology, London, United Kingdom, 6 Department of Psychology, Cardiff University, Cardiff, United Kingdom, 7 Department of Industrial and Information Engineering, University of Pavia, Pavia, Italy, 8 National Institute for Health Research, UCLH Biomedical Research Centre, London, United Kingdom, 9 Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy

In addition to motor functions, growing evidence indicates that in humans the cerebellum plays a significant role in cognition. This is occurs through connections with cerebral associative areas via synapsis in the thalamus. While recognizing that tractography provides an indirect evidence of anatomical connectivity between regions, using advanced diffusion MRI tractography we aimed to characterise the cerebello-thalamo-cortical pathway in terms of functional and anatomical areas touched by streamlines. Almost 80% of the streamlines reached the cerebellar hemispheres on one side and the associative cerebral cortex on the other, suggesting a prominent connectivity and supporting the coevolution of the two structures.

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