Abstract #0119
Contralateral cerebello-thalamo-cortical pathways with prominent involvement of associative areas in humans in vivo
Fulvia Palesi 1,2 , Donald Tournier 3,4 , Fernando Calamante 3,4 , Nils Muhlert 5,6 , Gloria Castellazzi 2,7 , Declan Chard 5,8 , Egidio D'Angelo 2,9 , and Claudia A. M. Wheeler-Kingshott 5
1
Department of Physics, University of Pavia,
Pavia, Pavia, Italy,
2
Brain
Connectivity Center, National Neurological Institute C.
Mondino, Pavia, Pavia, Italy,
3
The
Florey Institute of Neuroscience and Mental Health,
Melbourne Brain Centre, Heidelberg, Australia,
4
Department
of Medicine, Austin Health and Northern Health,
University of Melbourne, Heidelberg, Australia,
5
NMR
Research Unit, Department of Neuroinflammation, Queen
Square MS Centre, UCL Institute of Neurology, London,
United Kingdom,
6
Department
of Psychology, Cardiff University, Cardiff, United
Kingdom,
7
Department
of Industrial and Information Engineering, University of
Pavia, Pavia, Italy,
8
National
Institute for Health Research, UCLH Biomedical Research
Centre, London, United Kingdom,
9
Department
of Brain and Behavioural Sciences, University of Pavia,
Pavia, Italy
In addition to motor functions, growing evidence
indicates that in humans the cerebellum plays a
significant role in cognition. This is occurs through
connections with cerebral associative areas via synapsis
in the thalamus. While recognizing that tractography
provides an indirect evidence of anatomical connectivity
between regions, using advanced diffusion MRI
tractography we aimed to characterise the
cerebello-thalamo-cortical pathway in terms of
functional and anatomical areas touched by streamlines.
Almost 80% of the streamlines reached the cerebellar
hemispheres on one side and the associative cerebral
cortex on the other, suggesting a prominent connectivity
and supporting the coevolution of the two structures.
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