Abstract #0116
Monitoring vascular permeability and remodelling following endothelial injury in a murine model using an MR albumin binding contrast agent
Begoa Lavin Plaza 1 , Alkystis Phinikaridou 1 , Silvia Lorrio Gonzalez 1 , Carlos Zaragoza Sanchez 2 , and Rene Botnar 1
1
King's College London, London, United
Kingdom,
2
Centro
Nacional Investigaciones Cardiovasculares, Spain
Endothelial cells play a critical role in maintaining
vascular homeostasis. However, vascular damage may lead
to endothelial dysfunction characterized by decreased
bioavailability of nitric oxide, a signalling molecule
involved in vasodilatation, with several anti-atherogenic
and anti-inflammatory properties. Previous studies have
shown that contrast enhanced MRI using gadofosveset, an
albumin binding gadolinium contrast agent, can detect
endothelial damage, angiogenesis and vascular
permeability in different animal models. In this study,
we explored whether imaging with gadofosveset could be
used to monitor endothelial cell recovery, permeability
and vessel wall remodelling in a murine model of aortic
endothelial denudation.
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