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Abstract #0109

Multiplatform reproducibility of 3D carotid vessel wall MRI

Niranjan Balu 1 , Jie Sun 1 , Daniel S. Hippe 1 , David Zhu 2 , Seong-Eun Kim 3 , John Roberts 3 , J. Kevin DeMarco 2 , Dennis L. Parker 3 , David Saloner 4 , Michael V. McConnell 5 , Chun Yuan 1 , and Thomas S. Hatsukami 1

1 Radiology, University of Washington, Seattle, WA, United States, 2 Radiology, Michigan State University, Lansing, MI, United States, 3 Radiology, Utah Center for Advanced Imaging Research, University of Utah, Salt Lake City, UT, United States, 4 Radiology, University of California San Francisco, San Francisco, CA, United States, 5 Stanford University, CA, United States

Large coverage 3D isotropic vessel MRI has recently been proposed for carotid atherosclerotic plaque characterization. Use of a multicontrast 3D MRI protocol for serial MRI studies of atherosclerosis requires standardized protocols across multiple scanner platforms for use in multicenter studies. Reproducibility of plaque measurements has not been established in a multicenter setting. We demonstrate using patients with 50-79% stenosis that a standardized 3D carotid MRI protocol can provide reproducible measurement across three major scanner platforms (GE, Philips and Siemens). Plaque burden measurements and identification of plaque components showed good to excellent reproducibility comparable to traditional 2D multicontrast vessel wall MRI.

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